About Acitretin Capsules

Acitretin 10/25 Capsule is a pharmaceutical product specifically formulated to address severe psoriasis and severe resistant psoriasis. It contains Acitretin as the active ingredient and offers systemic treatment for individuals who have not responded well to other therapies. 

Glasierwellness is a leading manufacturer and wholesale supplier of Acitretin Capsules in India

Packing of Acitretin Capsules

The Acitretin 10/25 Capsule is packed in a convenient 10x1x10 capsule arrangement. This packaging ensures an adequate supply of 100 capsules per pack, allowing for the prescribed treatment duration. The individual capsules are securely sealed in blister packaging, offering protection against moisture, light, and physical damage.

Compositions of Acitretin Capsules

Glacitret 10 Capsule Composition: 

Each Glacitret 10 Capsule contains 10 mg of Acitretin. Acitretin is a second-generation retinoid derived from vitamin A, specifically known as a synthetic aromatic analog of retinoic acid. It is a potent medication used in the treatment of severe psoriasis and severe resistant psoriasis. 

Acitretin acts by binding to and activating specific retinoic acid receptors (RARs), particularly RAR-β and RAR-γ. Once activated, these receptors modulate gene transcription, leading to the normalization of cell differentiation and proliferation. By regulating these cellular processes, Acitretin helps reduce the excessive growth and turnover of skin cells that occurs in psoriasis. 

Glacitret 25 Capsule Composition: 

Each Glacitret 25 Capsule contains 25 mg of Acitretin. This higher dosage variant provides a more potent form of Acitretin therapy for individuals with severe psoriasis and resistant cases that require a stronger treatment approach. 

Both the Glacitret 10 and Glacitret 25 Capsules contain the same active ingredient, Acitretin, but at different strengths. The choice of dosage depends on the severity and response to treatment, as determined by the healthcare professional. 

Acitretin undergoes extensive metabolism in the body, primarily in the liver, where it is converted into its active metabolite, etretinate. Etretinate exerts its therapeutic effects by modulating the expression of specific genes involved in cellular differentiation and proliferation.

When to Use Acitretin Capsules

Plaque Psoriasis: 

Acitretin 10 Capsule and Acitretin 25 Capsule are highly effective in the treatment of plaque psoriasis, a chronic and most common form of psoriasis. Plaque psoriasis is characterized by the development of raised, red patches on the skin covered with silvery scales. These patches can appear on various parts of the body, including the elbows, knees, scalp, and lower back. The symptoms of plaque psoriasis can be uncomfortable and can significantly impact a person's quality of life. 

Acitretin capsules provide a systemic treatment approach to manage and control the symptoms associated with plaque psoriasis. The active ingredient, Acitretin, a synthetic retinoid derived from vitamin A, works by binding to specific retinoic acid receptors (RARs) in the skin. This binding process helps modulate gene expression, promote normal cell differentiation and proliferation, and regulate the excessive growth and turnover of skin cells. 

By normalizing cell growth and reducing inflammation, Acitretin capsules improve the appearance of plaques, reducing redness, scaling, and thickness. This leads to smoother, clearer skin and a reduction in the associated itching and discomfort. The systemic nature of Glacitret capsules ensures that the medication reaches all areas of the body affected by plaque psoriasis, including hard-to-reach areas like the scalp, palms, and soles. 

Pustular Psoriasis: 

Acitretin 10 Capsule and Acitretin 25 Capsule are valuable treatment options for pustular psoriasis, a rare form of psoriasis characterized by the development of pus-filled blisters on the skin. Pustular psoriasis can occur in localized areas or spread across larger regions of the body, causing redness, scaling, and tenderness. 

The active ingredient in Acitretin capsules, Acitretin, plays a crucial role in managing pustular psoriasis. It targets the underlying mechanisms of the condition by reducing inflammation and regulating abnormal cell proliferation and differentiation. By modulating gene expression through binding to retinoic acid receptors, Acitretin helps normalize the growth and shedding of skin cells. 

Through its systemic action, Acitretin capsules effectively alleviate the symptoms associated with pustular psoriasis. The capsules aid in reducing inflammation, promoting the healing of blisters, and improving the overall appearance of the affected skin. This systemic approach ensures that the medication reaches all areas of the body where pustular psoriasis manifests, providing comprehensive relief and promoting healthier skin. 

Guttate Psoriasis: 

Acitretin 10 Capsule and Acitretin 25 Capsule are indicated for the treatment of guttate psoriasis, a form of psoriasis characterized by the appearance of small, red, teardrop-shaped lesions on the skin. Guttate psoriasis often develops after a streptococcal throat infection and can occur on the trunk, limbs, and scalp. The condition can be uncomfortable and cause itching, scaling, and dryness. 

The systemic treatment approach provided by Acitretin capsules offers significant benefits in managing guttate psoriasis. Acitretin, the active ingredient, works by reducing inflammation and modulating cell growth and differentiation. By targeting the underlying causes of guttate psoriasis, Acitretin helps normalize skin cell turnover and reduce the appearance of red, scaly lesions. 

Acitretin capsules aid in improving the overall appearance of the skin affected by guttate psoriasis. They effectively alleviate inflammation, reduce scaling and itching, and promote the healing of the lesions. The systemic nature of the medication ensures that all areas of the body affected by guttate psoriasis receive treatment, leading to improved skin health and enhanced well-being. 

Inverse Psoriasis: 

Acitretin 10 Capsule and Acitretin 25 Capsule offer effective treatment options for individuals with inverse psoriasis. Inverse psoriasis is characterized by the development of smooth, red patches in skin folds, such as the armpits, groin, and under the breasts. These areas are prone to friction, moisture, and limited exposure to air, making them susceptible to inflammation and irritation. 

The systemic treatment approach provided by Acitretin capsules is particularly beneficial for managing inverse psoriasis. Acitretin, the active ingredient in Glacitret, acts on specific retinoic acid receptors in the skin, regulating cellular processes and reducing inflammation. By modulating gene expression and promoting normal cell differentiation, Acitretin helps to normalize the excessive growth and turnover of skin cells in affected areas. 

Acitretin capsules effectively alleviate the symptoms associated with inverse psoriasis, including redness, itching, and discomfort. By reducing inflammation and promoting skin healing, the capsules improve the overall appearance of the affected skin folds, making them smoother and less prone to irritation. The systemic nature of the medication ensures that it reaches all areas of the body affected by inverse psoriasis, including the hard-to-reach folds, providing comprehensive relief and supporting better skin health. 

Erythrodermic Psoriasis: 

Acitretin 10 Capsule and Acitretin 25 Capsule are vital treatment options for individuals with erythrodermic psoriasis, a severe and rare form of psoriasis that affects most of the body. Erythrodermic psoriasis is characterized by widespread redness, shedding of the skin, and intense itching. It is a condition that significantly impacts a person's quality of life and requires prompt and effective management. 

The systemic treatment approach provided by Acitretin capsules is particularly beneficial for managing the symptoms associated with erythrodermic psoriasis. Acitretin, the active ingredient in Glacitret, acts on retinoic acid receptors in the skin, regulating cellular processes and reducing inflammation. By modulating gene expression, Acitretin helps to normalize cell growth, reduce excessive shedding of the skin, and promote healing. 

Acitretin capsules effectively alleviate inflammation, redness, and discomfort associated with erythrodermic psoriasis. By promoting the healing of the skin and reducing excessive scaling and itching, the capsules help to improve the overall appearance and condition of the affected skin. The systemic nature of the medication ensures that it reaches all areas of the body affected by erythrodermic psoriasis, providing comprehensive relief and supporting better skin health.

Benefits of Acitretin Capsules

• Acitretin 10/25 Capsule helps reduce the symptoms of severe psoriasis, such as redness, scaling, and thickness of the skin lesions.
• The medication works by slowing down the excessive growth of skin cells, promoting a more normal skin turnover process.
• By reducing the inflammation associated with psoriasis, Acitretin 10/25 Capsule helps alleviate itching and discomfort.
• The capsules provide targeted treatment for severe cases of psoriasis, offering relief to individuals who have not responded well to other treatments.
• Acitretin 10/25 Capsule may improve the appearance of the skin by reducing the size and severity of psoriatic lesions.
• The medication has the potential to enhance the quality of life for individuals with severe psoriasis, allowing them to engage in daily activities with less discomfort and self-consciousness.
• By controlling the symptoms of psoriasis, Acitretin 10/25 Capsule may help improve psychological well-being and self-esteem.
• Acitretin 10/25 Capsule may help prevent the recurrence of psoriatic flares and maintain long-term control over the condition.
• The medication offers an alternative treatment option for individuals who are unable to tolerate or have contraindications to other systemic therapies for psoriasis.
• Acitretin 10/25 Capsule can be used in combination with other psoriasis treatments, such as topical creams or phototherapy, to enhance the overall therapeutic effect.
• The capsules are designed for long-term use, allowing for continuous management of severe psoriasis.
• By reducing the severity of psoriasis symptoms, Acitretin 10/25 Capsule may contribute to an improved overall quality of life.
• The medication targets the underlying mechanisms of psoriasis, helping to control the disease at its source.
• Acitretin 10/25 Capsule may help reduce the extent and involvement of psoriasis on the body, leading to less coverage and smaller affected areas.
• The capsules offer a convenient dosage form, making it easier for individuals to adhere to their prescribed treatment regimen.
• By managing severe psoriasis, Acitretin 10/25 Capsule may help individuals engage in social activities and improve their interpersonal relationships.
• The medication's efficacy in treating severe resistant psoriasis provides hope and relief to individuals who have struggled to find an effective treatment option.
• Acitretin 10/25 Capsule may help prevent the progression of psoriasis to more severe forms, reducing the risk of complications.
• The medication's ability to control psoriasis symptoms allows individuals to regain a sense of control over their condition and actively participate in their own care.
• Acitretin 10/25 Capsule offers a systemic treatment approach, targeting psoriasis throughout the body, including hard-to-reach areas.
• The capsules provide a consistent and measured dosage of Acitretin, ensuring accurate and controlled administration.
• Acitretin 10/25 Capsule may help reduce the frequency and severity of psoriasis flares, leading to longer periods of remission.
• The medication's effectiveness in treating severe psoriasis can significantly improve the physical comfort and mobility of affected individuals.
• Acitretin 10/25 Capsule allows for individualized treatment plans based on the severity and response of each patient.
• The capsules offer a well-tolerated treatment option for severe psoriasis, with a low incidence of systemic side effects.
• Acitretin 10/25 Capsule may help prevent the progression of psoriasis to joint involvement, reducing the risk of developing psoriatic arthritis.
• The medication's therapeutic benefits extend beyond the skin, potentially improving associated symptoms, such as nail involvement and scalp psoriasis.
• Acitretin 10/25 Capsule provides a treatment option for individuals who require systemic therapy due to extensive psoriasis involvement.
• The capsules, when used as part of a comprehensive treatment plan, can contribute to long-term disease control and improved quality of life.

Direction for Use of Acitretin Capsules

• Follow the instructions provided by your healthcare professional regarding the dosage and duration of treatment. Do not alter the prescribed dosage without consulting your healthcare provider.
• Acitretin 10/25 Capsule is taken orally with a glass of water. Swallow the capsule whole without crushing or chewing it.
• It is recommended to take Acitretin 10/25 Capsule with food to enhance its absorption and reduce the potential for gastrointestinal side effects. Follow the guidance of your healthcare professional regarding the timing of administration with meals.
• Adhere to the prescribed schedule and take the medication at the same time each day to maintain consistent therapeutic levels in the body.
• If you miss a dose, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.
• It is important to complete the full course of treatment unless otherwise directed by your healthcare professional, even if the symptoms improve. Stopping the medication abruptly may result in the recurrence of symptoms.

How to Storage Acitretin Capsules

• Store Acitretin 10/25 Capsule in its original packaging to protect it from moisture and light.
• Keep the medication out of the reach of children and pets.
• Store at room temperature, away from excessive heat and humidity.
• Do not use the capsules after the expiration date printed on the packaging. Discard any expired medication properly according to local regulations.

Caution:

• Acitretin 10/25 Capsule should only be used under the supervision and prescription of a qualified healthcare professional experienced in the treatment of psoriasis.
• Please carefully read the patient information leaflet provided inside the pack.
• Inform your healthcare provider about any other medications, supplements, or herbal products you are taking, as they may interact with Acitretin 10/25 Capsule.
• Women of childbearing potential should use effective contraception during treatment with Acitretin 10/25 Capsule and for at least three years after discontinuation due to the potential for severe birth defects. Discuss appropriate contraception methods with your healthcare provider.
• Inform your healthcare provider if you have a history of liver disease, kidney disease, high blood lipid levels, or any other significant medical condition before starting treatment with Acitretin 10/25 Capsule.
• Regular monitoring and follow-up appointments with your healthcare professional are important to assess the effectiveness of the medication and monitor for any potential side effects.
• Avoid excessive exposure to sunlight or artificial ultraviolet (UV) light during treatment with Acitretin 10/25 Capsule, as it may increase the risk of sunburn or photosensitivity reactions. Apply appropriate sun protection measures and use sunscreen when outdoors.
• If you experience any severe or persistent side effects or have any concerns during the course of treatment, promptly contact your healthcare professional for further guidance.
• Do not share your medication with others, even if they have similar symptoms or conditions.
• Read the patient information leaflet provided with the medication for additional important information and instructions.

Disclaimer:

The following disclaimer provides important information regarding the use of Acitretin 10/25 Capsule. It is essential to read and understand this disclaimer before using the medication: 

Prescription Medication:  Acitretin 10/25 Capsule is a prescription medication and should only be used under the supervision and prescription of a qualified healthcare professional experienced in the treatment of psoriasis. Do not self-medicate or adjust the dosage without consulting your healthcare provider. 

Individualized Treatment: The use of Acitretin 10/25 Capsule may vary depending on individual factors, including the severity of the condition, medical history, response to treatment, and potential risks and benefits. The information provided here is not a substitute for personalized medical advice. Always consult your healthcare professional for guidance specific to your situation. 

Effectiveness and Side Effects: The effectiveness of Acitretin 10/25 Capsule and the occurrence of side effects may differ from person to person. While the medication has been shown to be effective in managing severe psoriasis and severe resistant psoriasis, individual responses may vary. It is important to discuss potential benefits and risks with your healthcare provider. 

Monitoring and Follow-up: Regular monitoring and follow-up appointments with your healthcare professional are crucial during the course of treatment with Acitretin 10/25 Capsule. This ensures that the medication is being appropriately managed and that any potential side effects or concerns can be addressed promptly. 

Contraindications and Precautions:  Acitretin 10/25 Capsule may not be suitable for everyone. Certain medical conditions, such as liver disease, kidney disease, high blood lipid levels, and pregnancy, may require special precautions or contraindicate the use of this medication. Inform your healthcare provider about any pre-existing medical conditions or medications you are taking before starting treatment. 

Potential Interactions:  Acitretin 10/25 Capsule may interact with other medications, supplements, or herbal products. It is important to disclose all the medications you are taking to your healthcare provider to avoid potential interactions that may reduce efficacy or increase the risk of side effects. 

Birth Defects and Contraception:  Acitretin 10/25 Capsule has the potential to cause severe birth defects. Women of childbearing potential should use effective contraception during treatment and for at least three years after discontinuation. Discuss appropriate contraception methods with your healthcare provider. 

Sun Exposure: Avoid excessive exposure to sunlight or artificial ultraviolet (UV) light during treatment with Acitretin 10/25 Capsule, as it may increase the risk of sunburn or photosensitivity reactions. Apply appropriate sun protection measures and use sunscreen when outdoors. 

Adherence to Instructions: It is important to follow the instructions provided by your healthcare professional regarding the dosage, timing, and duration of treatment with Acitretin 10/25 Capsule. Adhering to the prescribed regimen ensures optimal efficacy and reduces the risk of potential complications. 

Read Patient Information Leaflet: The patient information leaflet provided with Acitretin 10/25 Capsule contains important information regarding the medication, including precautions, potential side effects, and instructions for use. Read the leaflet carefully and contact your healthcare provider if you have any questions or concerns.